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Literature summary extracted from

  • Tadera, K.; Minami, Y.; Takamatsu, K.; Matsuoka, T.
    Inhibition of alpha-glucosidase and alpha-amylase by flavonoids (2006), J. Nutr. Sci. Vitaminol., 52, 149-153.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.20 apigenin
-
 Saccharomyces cerevisiae
3.2.1.20 baicalein 16% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 baicalein
-
 Saccharomyces cerevisiae
3.2.1.20 catechin
-
 Saccharomyces cerevisiae
3.2.1.20 cyanidin 6% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 cyanidin
-
 Saccharomyces cerevisiae
3.2.1.20 daidzein mixed type Saccharomyces cerevisiae
3.2.1.20 epicatechin 5% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 epicatechin
-
 Saccharomyces cerevisiae
3.2.1.20 epigallocatechin 7% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 epigallocatechin
-
 Saccharomyces cerevisiae
3.2.1.20 epigallocatechin gallate 32% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 epigallocatechin gallate mixed type, nearly noncompetitive inhibition Saccharomyces cerevisiae
3.2.1.20 fisetin 26% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 fisetin
-
 Saccharomyces cerevisiae
3.2.1.20 genistein mixed type Saccharomyces cerevisiae
3.2.1.20 hesperetin
-
 Saccharomyces cerevisiae
3.2.1.20 kaempferol 8% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 kaempferol
-
 Saccharomyces cerevisiae
3.2.1.20 luteolin 19% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 luteolin mixed type, nearly noncompetitive inhibition Saccharomyces cerevisiae
3.2.1.20 additional information no inhibition by daidzein, catechin, apigenin, hesperetin, naringenin, and genistein at 0.5 mM Rattus norvegicus
3.2.1.20 myricetin 29% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 myricetin mixed type, nearly noncompetitive inhibition Saccharomyces cerevisiae
3.2.1.20 naringenin mixed type, nearly noncompetitive inhibition Saccharomyces cerevisiae
3.2.1.20 quercetin 28% inhibition at 0.5 mM Rattus norvegicus
3.2.1.20 quercetin mixed type, nearly noncompetitive inhibition Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.20 Rattus norvegicus
-
-
-
3.2.1.20 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.20 commercial preparation
-
 Saccharomyces cerevisiae
-
3.2.1.20 small intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.20 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Saccharomyces cerevisiae 4-nitrophenol + alpha-D-glucose
-
 ?
3.2.1.20 maltose + H2O
-
 Rattus norvegicus alpha-D-glucose + D-glucose
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.20 30
-
 assay at Saccharomyces cerevisiae
3.2.1.20 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.20 6
-
 assay at Rattus norvegicus
3.2.1.20 6.8
-
 assay at Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.20 0.002
-
 pH 6.8, 30°C Saccharomyces cerevisiae epigallocatechin gallate
3.2.1.20 0.004
-
 pH 6.8, 30°C Saccharomyces cerevisiae cyanidin
3.2.1.20 0.005
-
 pH 6.8, 30°C Saccharomyces cerevisiae myricetin
3.2.1.20 0.007
-
 pH 6.8, 30°C Saccharomyces cerevisiae quercetin
3.2.1.20 0.007
-
 pH 6.8, 30°C Saccharomyces cerevisiae genistein
3.2.1.20 0.012
-
 pH 6.8, 30°C Saccharomyces cerevisiae kaempferol
3.2.1.20 0.013
-
 pH 6.8, 30°C Saccharomyces cerevisiae fisetin
3.2.1.20 0.014
-
 pH 6.8, 30°C Saccharomyces cerevisiae daidzein
3.2.1.20 0.021
-
 pH 6.8, 30°C Saccharomyces cerevisiae luteolin
3.2.1.20 0.075
-
 pH 6.8, 30°C Saccharomyces cerevisiae naringenin
3.2.1.20 0.075
-
 pH 6.8, 30°C Saccharomyces cerevisiae epigallocatechin
3.2.1.20 0.15
-
 pH 6.8, 30°C Saccharomyces cerevisiae hesperetin
3.2.1.20 0.2
-
 above, pH 6.8, 30°C Saccharomyces cerevisiae apigenin
3.2.1.20 0.2
-
 above, pH 6.8, 30°C Saccharomyces cerevisiae baicalein
3.2.1.20 0.2
-
 above, pH 6.8, 30°C Saccharomyces cerevisiae epicatechin
3.2.1.20 0.2
-
 above, pH 6.8, 30°C Saccharomyces cerevisiae catechin