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Literature summary extracted from

  • Santone, R.; Giorgi, M.; Maccarone, R.; Basso, M.; Deplano, S.; Bisti, S.
    Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina (2006), J. Neurosci. Res., 84, 1020-1026.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.17 Ca2+ isoform PDE1, stimulation of both hydrolysis of cAMP and cGMP Rattus norvegicus
3.1.4.17 Calmodulin isoform PDE1, stimulation of both hydrolysis of cAMP and cGMP Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.17 63000
-
 x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A Rattus norvegicus
3.1.4.17 70000
-
 x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A Rattus norvegicus
3.1.4.17 74000
-
 x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A Rattus norvegicus
3.1.4.17 79000
-
 x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Rattus norvegicus
-
 isoform PDE1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 retina splice variant PDE1A is distributed in outer retina, especially in the outer segments of photoreceptors. Variant PDE1B is uniformly distributed across the retina, PDE1C is confined mainly to the inner retina with precise localization to the inner nuclear layer Rattus norvegicus
-

Subunits

EC Number Subunits Comment Organism
3.1.4.17 ? x * 63000, splice variant PDE1B, x * 74000 and x * 70000, splice variant PDE1C, x * 79000, splice variant PDE1A Rattus norvegicus