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Literature summary extracted from

  • Wachten, S.; Schlenstedt, J.; Gauss, R.; Baumann, A.
    Molecular identification and functional characterization of an adenylyl cyclase from the honeybee (2006), J. Neurochem., 96, 1580-1590.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 Ca2+
-
 Apis mellifera
4.6.1.1 forskolin
-
 Apis mellifera
4.6.1.1 Gsalpha signal transduction from beta-adrenergic receptors via trimeric Gs proteins to their downstream targets, e.g. ACs Apis mellifera
4.6.1.1 additional information neither ionomycin nor thapsigargin activate Apis mellifera
4.6.1.1 norepinephrine activates endogenously expressed b-adrenergic receptors, signal transduction from beta-adrenergic receptors via trimeric Gs proteins to their downstream targets, e.g. ACs Apis mellifera

Application

EC Number Application Comment Organism
4.6.1.1 additional information shares high sequence similarity (approximately 62%) with the Drosophila AC39E, enzyme serves in biogenic amine signal transduction cascades and in higher brain functions that contribute to learning and memory of the bee Apis mellifera

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 construction of a pcAmac3-HA expression vector, heterologous expression in flp-In-293 cells Apis mellifera

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 membrane
-
 Apis mellifera 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Mg2+
-
 Apis mellifera

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.1 101000
-
 Western blot analysis Apis mellifera
4.6.1.1 108000
-
 Western blot analysis Apis mellifera
4.6.1.1 110900
-
 sequence analysis Apis mellifera

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Apis mellifera Q1MU16
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 brain highly expressed in somata of mushroom body neurones Apis mellifera
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Apis mellifera 3',5'-cAMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 Amac3
-
 Apis mellifera
4.6.1.1 group 1 adenylyl cyclase
-
 Apis mellifera