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Literature summary extracted from

  • Lee, E.; Hayes, D.B.; Langsetmo, K.; Sundberg, E.J.; Tao, T.C.
    Interactions between the leucine-zipper motif of cGMP-dependent protein kinase and the C-terminal region of the targeting subunit of myosin light chain phosphatase (2007), J. Mol. Biol., 373, 1198-1212.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.53 in Escherichia coli, expression of various C-terminal MYPT1 peptides bearing various combinations of a predicted coiled coil region, extensions preceding this coiled coil region, and the leucine-zipper motif Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.53 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.53 of the recombinant peptides by chitin beads Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.53 aortic smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.53 myosin light-chain phosphate + H2O muscle Homo sapiens myosin light-chain + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.53 More The leucine-zipper motif at the N terminus of PKG forms a homodimeric coiled coil, the one at the C terminus of MYPT1 is monomeric and non-helical. The leucine-zipper motif of PKG binds to that of MYPT1 to form a heterodimer. When the leucine-zipper motif of MYPT1 is absent, the PKG leucine-zipper motif binds to the coiled coil region and upstream segments of MYPT1 via formation of a heterotetramer Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.53 MLCP
-
 Homo sapiens
3.1.3.53 myosin light chain phosphatase
-
 Homo sapiens
3.1.3.53 MYPT1 the targeting subunit of MLCP Homo sapiens