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Literature summary extracted from

  • Huang, M.; Xie, S.X.; Ma, Z.Q.; Huang, Q.Q.; Nan, F.J.; Ye, Q.Z.
    Inhibition of monometalated methionine aminopeptidase: inhibitor discovery and crystallographic analysis (2007), J. Med. Chem., 50, 5735-5742.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.11.18 in complex with inhibitor, hanging drop vapour diffusion method with 10-15% PEG 20 000, 0.1 M MES (pH 6.5) and 0.2 mM or 0.8 mM MnCl2 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.18 5-(2-chlorophenyl)furan-2-carbohydrazide
-
 Escherichia coli
3.4.11.18 5-(2-chlorophenyl)furan-2-carboxylic acid
-
 Escherichia coli
3.4.11.18 imidazo[2,1-a]isoquinoline-2-carbohydrazide
-
 Escherichia coli
3.4.11.18 norleucine phosphonate
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.18 Mn2+
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.18 Escherichia coli P0AE18
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.18
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.18 L-methionine-7-amido-4-methylcoumarin + H2O
-
 Escherichia coli L-methionine + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.18 MetAP
-
 Escherichia coli
3.4.11.18 methionine aminopeptidase
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.11.18 0.00051
-
 in the presence of 0.1 mM Mn2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carboxylic acid
3.4.11.18 0.00064
-
 in the presence of 0.005 mM Mn2+ Escherichia coli imidazo[2,1-a]isoquinoline-2-carbohydrazide
3.4.11.18 0.00078
-
 in the presence of 0.005 mM Mn2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carboxylic acid
3.4.11.18 0.00116
-
 in the presence of 0.005 mM Mn2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carbohydrazide
3.4.11.18 0.00244
-
 in the presence of 0.001 mM Co2+ Escherichia coli imidazo[2,1-a]isoquinoline-2-carbohydrazide
3.4.11.18 0.00431
-
 in the presence of 0.1 mM Mn2+ Escherichia coli imidazo[2,1-a]isoquinoline-2-carbohydrazide
3.4.11.18 0.00578
-
 in the presence of 0.01 mM Ni2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carbohydrazide
3.4.11.18 0.00615
-
 in the presence of 0.01 mM Ni2+ Escherichia coli imidazo[2,1-a]isoquinoline-2-carbohydrazide
3.4.11.18 0.00656
-
 in the presence of 0.1 mM Mn2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carbohydrazide
3.4.11.18 0.0174
-
 in the presence of 0.006 mM Fe2+ Escherichia coli imidazo[2,1-a]isoquinoline-2-carbohydrazide
3.4.11.18 0.0278
-
 in the presence of 0.1 mM Co2+ Escherichia coli imidazo[2,1-a]isoquinoline-2-carbohydrazide
3.4.11.18 0.058
-
 in the presence of 0.006 mM Fe2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carbohydrazide
3.4.11.18 0.0771
-
 in the presence of 0.1 mM Co2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carbohydrazide
3.4.11.18 0.116
-
 in the presence of 0.006 mM Fe2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carboxylic acid
3.4.11.18 0.138
-
 in the presence of 0.1 mM Co2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carboxylic acid
3.4.11.18 0.141
-
 in the presence of 0.01 mM Ni2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carboxylic acid
3.4.11.18 0.2
-
 IC50 above 0.2 mM, in the presence of 0.001 mM Co2+ Escherichia coli 5-(2-chlorophenyl)furan-2-carboxylic acid