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Literature summary extracted from

  • Wen, C.; Kuo, Y.; Jan, J.; Liang, P.; Wang, S.; Liu, H.; Lee, C.; Chang, S.; Kuo, C.; Lee, S.; Hou, C.; Hsiao, P.; Chien, S.; Shyur, L.; Yang, N.
    Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus (2007), J. Med. Chem., 50, 4087-4095.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.69 betulinic acid competitive Severe acute respiratory syndrome-related coronavirus
3.4.22.69 curcumin
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 niclosamide
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 savinin competitive Severe acute respiratory syndrome-related coronavirus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.69 Severe acute respiratory syndrome-related coronavirus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.22.69 SARS-CoV 3CL protease
-
 Severe acute respiratory syndrome-related coronavirus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.69 0.0082
-
 betulinic acid
-
 Severe acute respiratory syndrome-related coronavirus
3.4.22.69 0.0091
-
 savinin
-
 Severe acute respiratory syndrome-related coronavirus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.22.69 0.01
-
-
 Severe acute respiratory syndrome-related coronavirus betulinic acid
3.4.22.69 0.025
-
-
 Severe acute respiratory syndrome-related coronavirus savinin
3.4.22.69 0.04
-
-
 Severe acute respiratory syndrome-related coronavirus curcumin
3.4.22.69 0.04
-
-
 Severe acute respiratory syndrome-related coronavirus niclosamide