EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.11.2 | analysis | detection of Pseudomonas aeruginosa based on chromogenic aminopeptidase N substrate 7-N-(beta-alanyl)amino-1-pentylphenoxazin-3-one with low degree of diffusion in nutrient media and a bright red colour of the product | Pseudomonas aeruginosa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.20 | 1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (4-phenyl-butyl)-amide | - |
Plasmodium falciparum | |
3.4.11.20 | 1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 4-fluoro-benzylamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-(4-benzyl-piperidine-1-carbonyl)-4-methyl-pentanoic acid hydroxyamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-propionamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-3-(4-benzyl-piperazin-1-yl)-N-hydroxy-3-oxo-propionamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-propionamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-(2,2-diphenyl-ethyl)-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-(4-chloro-benzyl)-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-(4-fluoro-benzyl)-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-biphenyl-3-ylmethyl-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-hydroxy-N'-(2-methyl-benzyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-hydroxy-N'-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-hydroxy-N'-(3-phenyl-propyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-hydroxy-N'-(4-phenyl-butyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-hydroxy-N'-indan-2-yl-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-hydroxy-N'-naphthalen-1-ylmethyl-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2-benzyl-N-hydroxy-N'-phenethyl-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 2N-dibenzyl-N'-hydroxy-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | 3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-2-(3-phenoxy-benzyl)-propionamide | - |
Plasmodium falciparum | |
3.4.11.20 | 3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-2-(3-phenoxybenzyl)-propionamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-(4-chloro-benzyl)-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-(4-chloro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-(4-fluoro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(E)-ylidene]-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-benzyl-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-benzyl-N'-hydroxy-2-isobutyl-malonamide | in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(3-phenyl-propyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-phenyl-butyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-trifluoromethyl-benzyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-isobutyl-N'-(1,2,3,4-tetrahydro-naphthalen-1-yl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-isobutyl-N'-(3-phenoxy-benzyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-isobutyl-N'-(3-phenyl-propyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-isobutyl-N'-(4-phenyl-butyl)-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-isobutyl-N'-naphthalen-1-ylmethyl-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-2-isobutyl-N'-phenethyl-malonamide | - |
Plasmodium falciparum | |
3.4.11.20 | N-hydroxy-N'-(4-phenyl-butyl)-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | - |
Plasmodium falciparum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.11.2 | Pseudomonas aeruginosa | - |
- |
- |
3.4.11.20 | Plasmodium falciparum | - |
- |
- |
3.4.11.20 | Plasmodium falciparum FcB1 | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.2 | 7-N-(beta-alanyl)amino-1-pentylphenoxazin-3-one + H2O | chromogenic substrate | Pseudomonas aeruginosa | alanine + 7-amino-1-pentylphenoxazin-3-one | - |
? | |
3.4.11.20 | L-Leu-p-nitroanilide + H2O | - |
Plasmodium falciparum | L-Leu + p-nitroaniline | - |
? | |
3.4.11.20 | L-Leu-p-nitroanilide + H2O | - |
Plasmodium falciparum FcB1 | L-Leu + p-nitroaniline | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.11.20 | PfA-M1 | belongs to the M1 family and displays a strict aminopeptidase activity at pH 7.4 and a broad substrate spectrum | Plasmodium falciparum |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.11.20 | 0.000006 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | |
3.4.11.20 | 0.000013 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-N'-(4-phenyl-butyl)-2-[1-phenyl-meth-(Z)-ylidene]-malonamide | |
3.4.11.20 | 0.000027 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-(4-fluoro-benzyl)-N'-hydroxy-malonamide | |
3.4.11.20 | 0.000041 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(2-methyl-benzyl)-malonamide | |
3.4.11.20 | 0.000045 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(3-phenoxy-benzyl)-malonamide | |
3.4.11.20 | 0.000046 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(4-phenyl-butyl)-malonamide | |
3.4.11.20 | 0.000091 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-naphthalen-1-ylmethyl-malonamide | |
3.4.11.20 | 0.000107 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-naphthalen-1-ylmethyl-malonamide | |
3.4.11.20 | 0.000109 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(1,2,3,4-tetrahydro-naphthalen-1-yl)-malonamide | |
3.4.11.20 | 0.000125 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2N-dibenzyl-N'-hydroxy-malonamide | |
3.4.11.20 | 0.000125 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(3-phenyl-propyl)-malonamide | |
3.4.11.20 | 0.00013 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-chloro-benzyl)-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | |
3.4.11.20 | 0.000164 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-benzyl-N'-hydroxy-2-(3-phenoxy-benzyl)-malonamide | |
3.4.11.20 | 0.00017 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-(4-chloro-benzyl)-N'-hydroxy-malonamide | |
3.4.11.20 | 0.000206 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-propionamide | |
3.4.11.20 | 0.000225 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-phenyl-butyl)-malonamide | |
3.4.11.20 | 0.000231 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(4-trifluoromethyl-benzyl)-malonamide | |
3.4.11.20 | 0.000248 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 3-(4-benzyl-piperidin-1-yl)-N-hydroxy-3-oxo-2-(3-phenoxybenzyl)-propionamide | |
3.4.11.20 | 0.000253 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-propionamide | |
3.4.11.20 | 0.00033 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-fluoro-benzyl)-N'-hydroxy-2-[1-phenyl-meth-(E)-ylidene]-malonamide | |
3.4.11.20 | 0.000406 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-(4-benzyl-piperidine-1-carbonyl)-4-methyl-pentanoic acid hydroxyamide | |
3.4.11.20 | 0.000495 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-benzyl-N'-hydroxy-2-isobutyl-malonamide | |
3.4.11.20 | 0.000527 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-(3-phenoxy-benzyl)-N'-(3-phenyl-propyl)-malonamide | |
3.4.11.20 | 0.00079 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(3-phenyl-propyl)-malonamide | |
3.4.11.20 | 0.000885 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-phenethyl-malonamide | |
3.4.11.20 | 0.000904 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-chloro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | |
3.4.11.20 | 0.000966 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 3-(3,4-dihydro-1H-isoquinolin-2-yl)-N-hydroxy-3-oxo-2-(3-phenoxy-benzyl)-propionamide | |
3.4.11.20 | 0.001011 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-phenethyl-malonamide | |
3.4.11.20 | 0.001149 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-hydroxy-2-isobutyl-N'-(4-phenyl-butyl)-malonamide | |
3.4.11.20 | 0.001168 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-biphenyl-3-ylmethyl-N'-hydroxy-malonamide | |
3.4.11.20 | 0.00176 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-3-(4-benzyl-piperazin-1-yl)-N-hydroxy-3-oxo-propionamide | |
3.4.11.20 | 0.001931 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-indan-2-yl-malonamide | |
3.4.11.20 | 0.002515 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-hydroxy-N'-(3-phenoxy-benzyl)-malonamide | |
3.4.11.20 | 0.003896 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | N-(4-fluoro-benzyl)-N'-hydroxy-2-isobutyl-malonamide | |
3.4.11.20 | 0.005363 | - |
in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 2-benzyl-N-(2,2-diphenyl-ethyl)-N'-hydroxy-malonamide | |
3.4.11.20 | 0.01 | - |
IC50 above 0.01 mM, in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid 4-fluoro-benzylamide | |
3.4.11.20 | 0.01 | - |
IC50 above 0.01 mM, in Tris-HCl buffer (25 mM, pH 7.4), at 25°C | Plasmodium falciparum | 1-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid (4-phenyl-butyl)-amide |