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Literature summary extracted from

  • Dax, C.; Duffieux, F.; Chabot, N.; Coincon, M.; Sygusch, J.; Michels, P.A.; Blonski, C.
    Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei (2006), J. Med. Chem., 49, 1499-1502.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
4.1.2.13 K156M identical to wild type enzyme Trypanosoma brucei
4.1.2.13 K16M not inhibited by 5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate Trypanosoma brucei
4.1.2.13 K239M identical to wild type enzyme Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.13 5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate 1 mM, 15 min incubation time, 80% residual activity Oryctolagus cuniculus
4.1.2.13 5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate 5 mM, 15 min incubation time, no residual activity Trypanosoma brucei
4.1.2.13 hexitol-1,6-bisphosphate strong competitive inhibitor Trypanosoma brucei
4.1.2.13 naphthalene-2,6-bisphosphate strong competitive inhibitor Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.13 Oryctolagus cuniculus
-
-
-
4.1.2.13 Trypanosoma brucei
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.2.13 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.13 D-fructose 1,6-bisphosphate
-
 Oryctolagus cuniculus glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate
-
 Trypanosoma brucei glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.1.2.13 dihydroxyacetone phosphate
-
 Oryctolagus cuniculus ?
-
 ?
4.1.2.13 dihydroxyacetone phosphate
-
 Trypanosoma brucei ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.13 class I fructose 1,6-bisphosphate aldolase
-
 Oryctolagus cuniculus
4.1.2.13 class I fructose 1,6-bisphosphate aldolase
-
 Trypanosoma brucei

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.2.13 0.0233
-
 5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate
-
 Trypanosoma brucei
4.1.2.13 0.028
-
 naphthalene-2,6-bisphosphate
-
 Trypanosoma brucei
4.1.2.13 0.045
-
 hexitol-1,6-bisphosphate
-
 Trypanosoma brucei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.2.13 0.02
-
 15 min incubation time Trypanosoma brucei 5-formyl-6-hydroxynaphthalen-2-yl dihydrogen phosphate