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Literature summary extracted from

  • Walton, K.A.; Gugiu, B.G.; Thomas, M.; Basseri, R.J.; Eliav, D.R.; Salomon, R.G.; Berliner, J.A.
    A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products (2006), J. Lipid Res., 47, 1967-1974.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 additional information 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine induces neutral sphingomyelinase activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 desipramine inhibits the acid SMase, and lipopolysaccharide induction of interleukin-8 synthesis in vivo Homo sapiens
3.1.4.12 GW4869 inhibits the neutral SMase, and lipopolysaccharide induction of interleukin-8 synthesis in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens a role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation, regulation, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 epithelial cell airway Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information a role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation, regulation, overview Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Homo sapiens
3.1.4.12 neutral sphingomyelinase
-
 Homo sapiens