EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.2.1.22 | D444N | basal activity of the recombinant D444N mutant is 1.5fold higher than that of wild-type enzyme under similar conditions but 1.3fold lower than wild-type enzyme in the presence of S-adenosyl-L-methionine. D444N mutant retains the ability to bind AdoMet albeit with reduced affinity | Homo sapiens |
4.2.1.22 | I437T | mutation results in loss of S-adenosyl-L-methionine-dependent activation but exhibits basal activity that is comparable to that of wild-type enzyme expressed under the same conditions. Purified recombinant I435T shows a two to 3fold higher basal activity compared to wild-type enzyme but is unresponsive to the allosteric activator S-adenosyl-L-methionine | Homo sapiens |
4.2.1.22 | additional information | structural insights into pathogenic mutations | Homo sapiens |
4.2.1.22 | S466L | mutant exhibits a higher basal activity than wild-type enzyme but cannot be further activated by the allosteric effecto S-adenosyl-L-methionine | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.22 | Homo sapiens | P35520 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.22 | L-serine + L-homocysteine | - |
Homo sapiens | cystathionine + H2O | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.22 | heme | - |
Homo sapiens |