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Literature summary extracted from

  • Schmid, A.; Sutto, Z.; Nlend, M.C.; Horvath, G.; Schmid, N.; Buck, J.; Levin, L.R.; Conner, G.E.; Fregien, N.; Salathe, M.
    Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP (2007), J. Gen. Physiol., 130, 99-109.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 CO2 induces acidification of cells, accompanied by a rise in intracellular HCO3- Homo sapiens
4.6.1.1 HCO3- mediates cAMP production Homo sapiens

Application

EC Number Application Comment Organism
4.6.1.1 additional information sAC is localized to motile airway cilia and it contributes to the regulation of human airway ciliary beat frequency in conditions of changing intracellular CO2/HCO3- via production of cAMP Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 ligated into pGEM-T Easy vector and expanded in DH5alpha Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 2-hydroxy-17beta-estradiol specific sAC inhibitor, blocks CO2/HCO3- mediated cAMP production Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.1 50000
-
 sAC form in axonemes, Western blot analysis Homo sapiens
4.6.1.1 75000
-
 Western blot analysis Homo sapiens
4.6.1.1 190000
-
 full-length form, Western blot analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.1 by gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 respiratory epithelium specific localization of the 50 kDa isoform to the axoneme of ciliated airway epithelial cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Homo sapiens 3',5'-cAMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 sAC
-
 Homo sapiens
4.6.1.1 soluble adenylyl cyclase
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.6.1.1 additional information
-
 ciliary beat frequency is stimulated by cAMP independently of intracellular pH Homo sapiens