EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.3.67 | 380-385A | in endothelial cells transfected with 380-385A (mutation on the PTEN phosphorylation site) phosphatidylinositol 3,4,5-trisphosphate immunofluorescence intensity is than in wildtype or G129R transfected cells. Phosphatidylinositol 3,4,5-trisphosphate intensity in endothelial cells transfected with 380385A is weak but gradually increases to a maximum at 240 min after cyclic strain stimulation by 1.48fold relative to static condition | Bos taurus |
3.1.3.67 | G129R | in endothelial cells transfected with G129R, that lacks both protein and lipid phosphatase activities, phosphatidylinositol 3,4,5-trisphosphate immunofluorescence intensity is higher than transfection with wildtype PTEN. phosphatidylinositol 3,4,5-trisphosphate immunofluorescence in endothelial cells transfected with G129R rapidly increases and is maximum at 60 min after cyclic strain stimulation by 2.14fold relative to static condition | Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.67 | additional information | PTEN is inhibited by cyclic strain: cyclic strain increases phosphatidylinositol 3,4,5-trisphosphate immunofluorescence and peaks at 60 min after cyclic strain stimulation by 1.93fold in endothelial cells | Bos taurus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.67 | Bos taurus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.3.67 | phosphoprotein | exposure of bovine aortic endothelial cells to cyclic strain results in a time-dependent PTEN phosphorylation. Maximal phosphorylation occurres at 10 min after the cyclic strain stimulation by 2.21fold relative to static condition | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.67 | endothelial cell | aortic endothelial cells, no change in PTEN protein expression in endothelial cells exposed to up to 24 h of cyclic strain | Bos taurus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.1.3.67 | additional information | - |
PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain. Inhibition of PTEN activity has no effect on cyclic strain-mediated cell proliferation but inhibits cyclic strain mediated suppression of apoptosis | Bos taurus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.67 | MMAC1/TEP1 | - |
Bos taurus |
3.1.3.67 | PTEN | - |
Bos taurus |