Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Willoughby, D.; Cooper, D.M.
    Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP (2006), J. Cell Sci., 119, 828-836.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 Carbachol carbachol-induced capacitative Ca2+ entry clearly stimulates AC8-mediated cAMP production at the single-cell level Homo sapiens
4.6.1.1 isoprenaline
-
 Homo sapiens
4.6.1.1 additional information prior activation of AC8 is not strictly necessary to observe Ca2+-driven cAMP dynamics. Nevertheless, amplitude of the transients is enhanced when AC8 is stimulated Homo sapiens
4.6.1.1 prostaglandin E1
-
 Homo sapiens
4.6.1.1 thapsigargin thapsigargin-induced capacitative Ca2+ entry clearly stimulates AC8-mediated cAMP production at the single-cell level Homo sapiens

Application

EC Number Application Comment Organism
4.6.1.1 additional information AC8 acts as a low-pass filter for high-frequency Ca2+ events, enhancing the regulatory options available to this signalling pathway Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Ca2+ during artificial or agonist-induced Ca2+ oscillations, periodic changes in cAMP that depended upon Ca2+ stimulation of AC8 with subsequent PKA-mediated phosphodiesterase 4 activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Homo sapiens 3',5'-cAMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC8
-
 Homo sapiens
4.6.1.1 type 8 adenylyl cyclase
-
 Homo sapiens