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Literature summary extracted from

  • Comess, K.M.; Schurdak, M.E.; Voorbach, M.J.; Coen, M.; Trumbull, J.D.; Yang, H.; Gao, L.; Tang, H.; Cheng, X.; Lerner, C.G.; McCall, J.O.; Burns, D.J.; Beutel, B.A.
    An ultraefficient affinity-based high-throughout screening process: application to bacterial cell wall biosynthesis enzyme MurF (2006), J. Biomol. Screen., 11, 743-754.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.10
-
 Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.10 2,4-dichloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-5-(morpholin-4-ylsulfonyl)benzamide
-
 Streptococcus pneumoniae
6.3.2.10 2-(propylamino)ethyl 4-amino-3-propoxybenzoate
-
 Streptococcus pneumoniae
6.3.2.10 2-chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)-5-[(diethylamino)sulfonyl]benzamide
-
 Streptococcus pneumoniae
6.3.2.10 2-thioxo-3-[4-(trifluoromethoxy)phenyl]-2,3-dihydroquinazolin-4(1H)-one
-
 Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.10 Streptococcus pneumoniae
-
-
-

Synonyms

EC Number Synonyms Comment Organism
6.3.2.10 MurF
-
 Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.2.10 0.001
-
-
 Streptococcus pneumoniae 2,4-dichloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-5-(morpholin-4-ylsulfonyl)benzamide
6.3.2.10 0.008
-
-
 Streptococcus pneumoniae 2-chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)-5-[(diethylamino)sulfonyl]benzamide
6.3.2.10 0.019
-
-
 Streptococcus pneumoniae 2-thioxo-3-[4-(trifluoromethoxy)phenyl]-2,3-dihydroquinazolin-4(1H)-one
6.3.2.10 0.03
-
-
 Streptococcus pneumoniae 2-(propylamino)ethyl 4-amino-3-propoxybenzoate