Literature summary extracted from

Liu, S.; Wang, H.; Currie, B.M.; Molinolo, A.; Leung, H.J.; Moayeri, M.; Basile, J.R.; Alfano, R.W.; Gutkind, J.S.; Frankel, A.E.; Bugge, T.H.; Leppla, S.H.
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature (2008), J. Biol. Chem., 283, 529-540.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.24.83	matrix metalloproteinase	matrix-metalloproteinase-activated lethal toxin has much lower in vivo toxicity than wild type toxin	Bacillus anthracis

Application

EC Number	Application	Comment	Organism
3.4.24.83	medicine	the antitumor toxin has potential for use in cancer therapy	Bacillus anthracis

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.4.24.83	89000	-	SDS-PAGE	Bacillus anthracis

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.83	Bacillus anthracis	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.83	mitogen-activated protein kinase kinase + H2O	-	Bacillus anthracis	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.83	anthrax lethal factor	-	Bacillus anthracis

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Release 2023.1 (January 2023)