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Literature summary extracted from

  • Baehr, W.; Karan, S.; Maeda, T.; Luo, D.G.; Li, S.; Bronson, J.D.; Watt, C.B.; Yau, K.W.; Frederick, J.M.; Palczewski, K.
    The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors (2007), J. Biol. Chem., 282, 8837-8847.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.6.1.2 additional information intrinsic requirement of guanylate cyclases for stability and/or transport of a set of membrane-associated phototransduction proteins Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 additional information GC1-/-, GC2-/- and GC1/GC2 double knock-out mice, GC1 expression level is maintained in GC2-/- retina and GC2 expression level is maintained in GC1-/- retina. Deletion of GC1 and GC2 renders rod and cone photoreceptors nonfunctional and unstable. In the rod outer segments of guanylate cyclase double knock-out mice, guanylate cyclase-activating proteins 1 and 2, and cyclic GMP phosphodiesterase are undetectable, although rhodopsin and transducin alpha-subunit are mostly unaffected. Outer segment membranes of GC1-/- and GC double knock-out cones are destabilized and devoid of cone transducin (alpha- and gamma-subunits), cone phosphodiesterase, and G protein-coupled receptor kinase 1, whereas cone pigments are present at reduced levels. Down-regulated proteins show normal RNA transcript levels, indicating that down-regulation is posttranslational Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Mus musculus
-
 C57BL/6J background
-
4.6.1.2 Mus musculus C57/BL6J
-
 C57BL/6J background
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 cone
-
 Mus musculus
-
4.6.1.2 retina
-
 Mus musculus
-
4.6.1.2 retinal rod
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 GC1
-
 Mus musculus
4.6.1.2 GC2
-
 Mus musculus
4.6.1.2 guanylate cyclase 1
-
 Mus musculus
4.6.1.2 guanylate cyclase 2
-
 Mus musculus