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Literature summary extracted from

  • Voglmeir, J.; Voglauer, R.; Wilson, I.B.
    XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity (2007), J. Biol. Chem., 282, 5984-5990.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.26 expressed in the xylosyltransferase-deficient pgsA-745 (S745) CHO cell line and in Pichia pastoris Homo sapiens
2.4.2.26 expression in Pichia pastoris. Soluble form of human XT-II is expressed in the xylosyltransferase-deficient pgsA-745 (S745) Chinese hamster ovary cell line Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.26 0.25
-
 UDP-D-xylose about Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.26 additional information active in the absence of any added cation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.26 additional information Homo sapiens first enzyme required for the generation of chondroitin and heparan sulfate glycosaminoglycan chains of proteoglycans ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.26 Homo sapiens Q86Y38
-
-
2.4.2.26 Homo sapiens Q9H1B5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.26 additional information first enzyme required for the generation of chondroitin and heparan sulfate glycosaminoglycan chains of proteoglycans Homo sapiens ?
-
 ?
2.4.2.26 UDP-D-xylose + bikunin
-
 Homo sapiens UDP + D-xylosyl-bikunin
-
 ?
2.4.2.26 UDP-D-xylose + DDDSIEGSGGR
-
 Homo sapiens UDP + DDDSIEG(D-xylosyl)SGGR
-
 ?
2.4.2.26 UDP-D-xylose + DDDSIEGSGGR syndecan peptide substrate Homo sapiens UDP + DDDSIEG(D-xylosyl)SGGR
-
 ?
2.4.2.26 UDP-D-xylose + DSISGDDLGSGDLGSGDFQR
-
 Homo sapiens ?
-
 ?
2.4.2.26 UDP-D-xylose + DSISGDDLGSGDLGSGDFQR
-
 Homo sapiens UDP + ?
-
 ?
2.4.2.26 UDP-D-xylose + QEEEGSGGGGQR
-
 Homo sapiens UDP + QEEEG(D-xylosyl)SGGGGQR
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.26 peptide O-xylosyltransferase
-
 Homo sapiens
2.4.2.26 peptide-O-xylosyltransferase
-
 Homo sapiens
2.4.2.26 XT-I
-
 Homo sapiens
2.4.2.26 XT-I isozyme Homo sapiens
2.4.2.26 XT-II
-
 Homo sapiens
2.4.2.26 XT-II isozyme Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.26 37
-
-
 Homo sapiens

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.4.2.26 15 37 15°C: about 40% of maximal activity, 37°C: maximal activity Homo sapiens
2.4.2.26 16 37
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.26 7.5 8
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.2.26 6.5 9 pH 6.5: about 60% of maximal activity, pH 9.0: about 60% of maximal activity Homo sapiens
2.4.2.26 6.5 8.5 pH 6.5: about 70% of maximal activity, pH 8.5: about 60% of maximal activity Homo sapiens