Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Charbonneau, M.; Harper, K.; Grondin, F.; Pelmus, M.; McDonald, P.P.; Dubois, C.M.
    Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells (2007), J. Biol. Chem., 282, 33714-33724.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.86 oxygen low oxygen concentrations enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region Rattus norvegicus
3.4.24.86 Tumor necrosis factor alpha 20 ng/ml tumor necrosis factor alpha enhances TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 synovial cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 p75 tumour necrosis factor receptor + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Rattus norvegicus soluble TNF-alpha
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 ADAM17
-
 Rattus norvegicus
3.4.24.86 TACE
-
 Rattus norvegicus
3.4.24.86 tumor necrosis factor-alpha converting enzyme
-
 Rattus norvegicus