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Literature summary extracted from

  • Lun, S.; Bishai, W.R.
    Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis (2007), J. Biol. Chem., 282, 18348-18356.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.1 expression as glutathione S-transferase fusion protein in Escherichia coli Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.1 D450A complete loss of activity Mycobacterium tuberculosis
3.1.1.1 H477A complete loss of activity Mycobacterium tuberculosis
3.1.1.1 additional information enzyme deletion results in reduced colony-forming unit loads in lungs and spleen and less lung pathology in BALB/mouse aerosol infection. Intravenous infection of mice with mutant cells results in significantly delayed time to death Mycobacterium tuberculosis
3.1.1.1 S215A complete loss of activity Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.1 dichlorvos
-
Mycobacterium tuberculosis
3.1.1.1 paraoxon
-
Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.1 0.738
-
4-methylumbelliferyl butanoate pH 7.0, 39°C Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.1 cell wall associated to Mycobacterium tuberculosis 5618
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.1 54000
-
PAGE Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Mycobacterium tuberculosis
-
isoform MT2282
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.1 lipoprotein lipoprotein associated with membrane, sequence analysis Mycobacterium tuberculosis
3.1.1.1 proteolytic modification sequence contains a N-terminal signal peptide Mycobacterium tuberculosis

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.1 recombinant protein Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 4-methylumbelliferyl butanoate + H2O enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate Mycobacterium tuberculosis 4-methylumbelliferol + butanoate
-
?
3.1.1.1 4-methylumbelliferyl heptanoate + H2O enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate Mycobacterium tuberculosis 4-methylumbelliferol + heptanoate
-
?
3.1.1.1 4-methylumbelliferyl oleate + H2O enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate Mycobacterium tuberculosis 4-methylumbelliferol + oleate
-
?
3.1.1.1 alpha-naphthyl acetate + H2O enzyme activity increases from acetate to propionate to butanoate substrate Mycobacterium tuberculosis alpha-naphthol + acetate
-
?
3.1.1.1 alpha-naphthyl butanoate + H2O enzyme activity increases from acetate to propionate to butanoate substrate Mycobacterium tuberculosis alpha-naphthol + butanoate
-
?
3.1.1.1 alpha-naphthyl propionate + H2O enzyme activity increases from acetate to propionate to butanoate substrate Mycobacterium tuberculosis alpha-naphthol + propionate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.1.1 monomer x * 54000, calculated Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 MT2282
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.1 39
-
-
Mycobacterium tuberculosis

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.1.1.1 37
-
activity is 10% lower than at 39°C Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.1 7
-
-
Mycobacterium tuberculosis