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Literature summary extracted from

  • Clarke, C.J.; Truong, T.G.; Hannun, Y.A.
    Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2 (2007), J. Biol. Chem., 282, 1384-1396.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 TNF-alpha increases N-SMase activity rapidly and transiently both endogenously and in cells overexpressing nSMase2, and induces membrane translocation of nSMase2, regulated by p38-alpha MAPK, the increase in endogenous N-SMase activity is abrogated by p38 MAPK inhibition Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 expression of V5-tagged nSMase2 in A-549 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 plasma membrane nSMase2 translocates acutely to the plasma membrane of A549 epithelial cells in response to tumor necrosis factor alpha, regulated by p38-alpha MAPK Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens role for nSMase2 in pro-inflammatory responses induced by TNF-alpha as a regulator of adhesion proteins, both p38-alpha MAPK and nSMase2 are involved in the TNF-alpha-stimulated up-regulation of the adhesion proteins vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 ?
-
?
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 A-549 cell epithelial cell Homo sapiens
-
3.1.4.12 epithelium
-
Homo sapiens
-
3.1.4.12 HUVEC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information role for nSMase2 in pro-inflammatory responses induced by TNF-alpha as a regulator of adhesion proteins, both p38-alpha MAPK and nSMase2 are involved in the TNF-alpha-stimulated up-regulation of the adhesion proteins vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 Homo sapiens ?
-
?
3.1.4.12 sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 N-SMase
-
Homo sapiens
3.1.4.12 neutral sphingomyelinase
-
Homo sapiens
3.1.4.12 nSMase2
-
Homo sapiens