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Literature summary extracted from

  • Nakagami, H.; Soukupova, H.; Schikora, A.; Zarsky, V.; Hirt, H.
    A Mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis (2006), J. Biol. Chem., 281, 38697-38704.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.25 H2O2 activates, MEKK1 kinase activity and protein stability is regulated by H2O2 in a proteasome-dependent manner Arabidopsis thaliana

Application

EC Number Application Comment Organism
2.7.11.25 additional information MEKK1 regulates multiple processes during vegetative development, accumulation of reactive oxygen species and redox homeostasis Arabidopsis thaliana

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.25 expression of Myc-tagged MEKK1 under the 35 S cauliflower mosaic virus promoter in Arabidopsis protoplasts Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.25 additional information MEKK1-deficient plants, are misregulated in the expression of a number of genes involved in cellular redox control and accumulate reactive oxygen species. Homozygous mekk1 mutant plants exhibit a lethal phenotype when developing true leaves. Mutant plants stay dwarfed and never reach maturity to produce seeds. Mekk1 and mpk4 mutant plants show similarities with respect to both, phenotype and H2O2 accumulation Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.25 protoplast
-
 Arabidopsis thaliana
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Arabidopsis thaliana
-
 Col-0 ecotype
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + MPK4
-
 Arabidopsis thaliana ADP + phosphorylated MPK4
-
 ?
2.7.11.25 ATP + myelin basic protein
-
 Arabidopsis thaliana ADP + phosphorylated myelin basic protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 MAPKKK
-
 Arabidopsis thaliana
2.7.11.25 MEKK1
-
 Arabidopsis thaliana
2.7.11.25 mitogen-activated protein kinase kinase kinase
-
 Arabidopsis thaliana