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Literature summary extracted from

  • Gruegelsiepe, H.; Brandt, O.; Hartmann, R.K.
    Antisense inhibition of RNase P: mechanistic aspects and application to live bacteria (2006), J. Biol. Chem., 281, 30613-30620.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.26.5 DNA 14-mer
-
 Escherichia coli
3.1.26.5 locked nucleic acid 14-mer
-
 Escherichia coli
3.1.26.5 peptide nucleic acid 14-mer
-
 Escherichia coli
3.1.26.5 peptide nucleic acid 14-mer PNA Pseudomonas aeruginosa
3.1.26.5 peptide nucleic acid 14-mer PNA Thermus thermophilus
3.1.26.5 RNA 14-mer
-
 Escherichia coli
3.1.26.5 RNA 14-mer
-
 Pseudomonas aeruginosa
3.1.26.5 RNA 14-mer
-
 Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.26.5 additional information Thermus thermophilus essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs ?
-
 ?
3.1.26.5 additional information Escherichia coli essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs ?
-
 ?
3.1.26.5 additional information Pseudomonas aeruginosa essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.26.5 Escherichia coli
-
-
-
3.1.26.5 Pseudomonas aeruginosa
-
-
-
3.1.26.5 Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.26.5 additional information essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs Thermus thermophilus ?
-
 ?
3.1.26.5 additional information essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs Escherichia coli ?
-
 ?
3.1.26.5 additional information essential ribonucleoprotein enzyme responsible for the 5'-end maturation of tRNAs Pseudomonas aeruginosa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.26.5 ribonuclease P
-
 Thermus thermophilus
3.1.26.5 ribonuclease P
-
 Escherichia coli
3.1.26.5 ribonuclease P
-
 Pseudomonas aeruginosa
3.1.26.5 RNase P
-
 Thermus thermophilus
3.1.26.5 RNase P
-
 Escherichia coli
3.1.26.5 RNase P
-
 Pseudomonas aeruginosa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.26.5 2 5 DNA 14-mer
-
 Escherichia coli
3.1.26.5 2.2
-
 RNA 14-mer
-
 Escherichia coli
3.1.26.5 3.9
-
 locked nucleic acid 14-mer
-
 Escherichia coli
3.1.26.5 12.5
-
 peptide nucleic acid 14-mer
-
 Escherichia coli