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Literature summary extracted from
- Role for an essential tyrosine in peptide amidation (2006), J. Biol. Chem., 281, 20873-20882.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.3.2.3 | into the pCIS vector for transfection of CHO cells | Rattus norvegicus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.3.2.3 | S767A | mutant is engineered to lack the N-glycosylation site at Asn765 | Rattus norvegicus |
| 4.3.2.3 | Y582F | mutant is engineered for analysing the role of the thyrosine residues for the activity of the enzyme | Rattus norvegicus |
| 4.3.2.3 | Y595F | mutant is engineered for analysing the role of the thyrosine residues for the activity of the enzyme | Rattus norvegicus |
| 4.3.2.3 | Y654F | mutant is engineered for analysing the role of the thyrosine residues for the activity of the enzyme | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.3.2.3 | EDTA | - |
Rattus norvegicus |  |
| 4.3.2.3 | EGTA | - |
Rattus norvegicus | |
| 4.3.2.3 | o-phenanthroline | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.3.2.3 | 0.65 | - |
ureidoglycolate | - |
Rattus norvegicus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.3.2.3 | Ca2+ | - |
Rattus norvegicus | |
| 4.3.2.3 | Fe3+ | - |
Rattus norvegicus | |
| 4.3.2.3 | Zn2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.2.3 | (S)-ureidoglycolate | Rattus norvegicus | - |
glyoxylate + urea | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.3.2.3 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.3.2.3 | HEK-293 PEAKrapid cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.2.3 | (S)-ureidoglycolate | - |
Rattus norvegicus | glyoxylate + urea | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.3.2.3 | PAL | - |
Rattus norvegicus |
| 4.3.2.3 | PAM | - |
Rattus norvegicus |
| 4.3.2.3 | peptidyl-alpha-hydroxyglycine alpha-amidating lyase | - |
Rattus norvegicus |
| 4.3.2.3 | peptidylglycine alpha-amidating monooxygenase | - |
Rattus norvegicus |
| 4.3.2.3 | UGL | - |
Rattus norvegicus |
| 4.3.2.3 | ureidoglycolate lyase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.3.2.3 | 37 | - |
activity assay | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.3.2.3 | 7.8 | - |
activity assay | Rattus norvegicus |
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Release 2023.1 (January 2023)
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