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Literature summary extracted from

  • Lind, M.I.; Missirlis, F.; Melefors, O.; Uhrigshardt, H.; Kirby, K.; Phillips, J.P.; Soederhaell, K.; Rouault, T.A.
    Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein (2006), J. Biol. Chem., 281, 18707-18714.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.3 overexpression in Escherichia coli, His-tag Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.3 additional information isoform IRP-1A specific overexpression in muscle results in pre-adult lethality Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.3 soluble
-
 Drosophila melanogaster
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.3 100000
-
 x * 100000, SDS-PAGE Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.3 Drosophila melanogaster Q9NFX2 isoforms IRP-1B, the isoform shows aconitase activity, but does not bind to iron-responsive elements
-
4.2.1.3 Drosophila melanogaster Q9NFX3 isoforms IRP-1A, the isoform shows aconitase activity, and additionally binds to iron-responsive elements
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.3 recombinant protein Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.3 cis-aconitate + H2O
-
 Drosophila melanogaster isocitrate
-
 ?
4.2.1.3 additional information isoform IRP-1A binds in vitro both Drosophila ferritin iron-responsive element and human ferritin iron-responsive element in the presence of a reducing agent Drosophila melanogaster ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.3 ? x * 100000, SDS-PAGE Drosophila melanogaster