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Literature summary extracted from

  • Klampfer, L.; Huang, J.; Swaby, L.A.; Augenlicht, L.
    Requirement of histone deacetylase activity for signaling by STAT1 (2004), J. Biol. Chem., 279, 30358-30368.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.98 medicine inhibitors of histone deacetylase activity sensitize colon cancer cells to interferon gamma-induced apoptosis through cooperative negative regulation of the Bcl-x expression Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.98 additional information silencing of isoforms HDAC1, HDAC2, HDAC3 by RNAi markedly decreases interferon gamma-driven gene activation. Overexpression of the enzymes enhances STAT1-driven transcriptional activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 Butyrate inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation Homo sapiens
3.5.1.98 suberoylanilide hydroxamic acid inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation Homo sapiens
3.5.1.98 trichostatin A inhibition of histone deacetylase activity, resulting in prevention of interferon gamma-induced Janus kinase 1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 HCT-116 cell
-
 Homo sapiens
-
3.5.1.98 HKE-3 cell
-
 Homo sapiens
-
3.5.1.98 HT-29 cell
-
 Homo sapiens
-