Literature summary extracted from

Phiel, C.J.; Zhang, F.; Huang, E.Y.; Guenther, M.G.; Lazar, M.A.; Klein, P.S.
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen (2001), J. Biol. Chem., 276, 36734-36741.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.5.1.98	expression in 293T, HeLa and Neuro2A cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.1.98	Valproic acid	treatment causes hyperacetylation of histones in cultured cells and activates transcription from diverse exogenous and endogenous promoters	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.98	Homo sapiens	-	-	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.5.1.98	0.4	-	isoform HDAC1, pH 8.0, 37°C	Homo sapiens	Valproic acid

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Release 2023.1 (January 2023)