Literature summary extracted from

Huang, X.; Kadonaga, J.T.
Biochemical analysis of transcriptional repression by Drosophila histone deacetylase 1 (2001), J. Biol. Chem., 276, 12497-12500.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.5.1.98	expression in Sf9 cells of full-length protein and of Gal4-dHDAC1, consisting of the N-terminal 147 amino acid residues of the yeast Gal4 protein fused to the N terminus of full-length dHDAC1 protein	Drosophila melanogaster

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.1.98	FR901228	Gal4-dHDAC1, consisting of the N-terminal 147 amino acid residues of the yeast Gal4 protein fused to the N terminus of full-length dHDAC1 protein, but not dHDAC1, is able to repress transcription in vitro. Transcriptional repression is blocked by the enzyme inhibitor FR901228	Drosophila melanogaster

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.1.98	Drosophila melanogaster	-	isoform dHDAC1, i.e. dRPD3	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.1.98	additional information	Gal4-dHDAC1, consisting of the N-terminal 147 amino acid residues of the yeast Gal4 protein fused to the N terminus of full-length dHDAC1 protein, but not dHDAC1, is able to repress transcription in vitro. Transcriptional repression is blocked by the enzyme inhibitor FR901228	Drosophila melanogaster	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.1.98	dRPD3	-	Drosophila melanogaster

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
3.5.1.98	additional information	deacetylation by isoform dHDAC1 does not require any additional cofactors	Drosophila melanogaster

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Release 2023.1 (January 2023)