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Literature summary extracted from

  • Swerdlow, R.D.; Green, C.L.; Setlow, B.; Setlow, P.
    Identification of an NADH-linked disulfide reductase from Bacillus megaterium specific for disulfides containing pantethine 4',4''-diphosphate moieties (1979), J. Biol. Chem., 254, 6835-6837.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.8 Priestia megaterium
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-
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Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.8
-
 Priestia megaterium

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.8 spore highest level in cells late in sporulation and in dormant spores Priestia megaterium
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.8 additional information the partially purified enzyme has no activity with cystine, GSSG or lipoic acid, and has high activity only with disulfides containing pantethine 4’,4”-diphosphate moieties either alone or as part of CoA. The enzyme utilizes only NADH as a reductant and is inactive with NADPH Priestia megaterium ?
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 ?
1.8.1.8 NADH + CoA-SS-CoA + H+
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 Priestia megaterium NAD+ + CoA
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 ?
1.8.1.8 NADH + CoA-SS-pantetheine-4'-phosphate
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 Priestia megaterium NAD+ + CoA + 4'-phosphopantetheine
-
 ?
1.8.1.8 NADH + pantethine 4',4''-diphosphate + H+
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 Priestia megaterium NAD+ + 4'-phosphopantetheine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.8 NADH-linked disulfide reductase
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 Priestia megaterium