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Literature summary extracted from

  • Korithoski, B.; Levesque, C.M.; Cvitkovitch, D.G.
    Involvement of the detoxifying enzyme lactoylglutathione lyase in Streptococcus mutans aciduricity (2007), J. Bacteriol., 189, 7586-7592.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.5 methylglyoxal addition at pH 5.0 results in a significant 98% increase in the glycolytic rate Streptococcus mutans
4.4.1.5 additional information is up-regulated during acid challenge, is induced during acidic growth 3.5fold and following acid adaptation 2fold, is up-regulated approximately 7fold during the exponential growth phase compared with that in the stationary growth phase Streptococcus mutans

Application

EC Number Application Comment Organism
4.4.1.5 medicine role in dental caries, LGL functions in the detoxification of methylglyoxal, resulting in increased aciduricity Streptococcus mutans

Protein Variants

EC Number Protein Variants Comment Organism
4.4.1.5 additional information lgl isogenic knockout mutant LGLKO, has no detectable enzyme activity, results in an acid-sensitive phenotype, glycolytic rate at pH 5.0 is higher for the mutant than for wild-type Streptococcus mutans

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 methylglyoxal addition at pH 7.0 results in a modest 28% decrease in the glycolytic rate Streptococcus mutans

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Streptococcus mutans
-
-
-
4.4.1.5 Streptococcus mutans UA159
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.4.1.5 46.2
-
 wild-type, at pH 5.0 Streptococcus mutans
4.4.1.5 68.7
-
 mutant, at pH 5.0 Streptococcus mutans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione + methylglyoxal
-
 Streptococcus mutans S-D-lactoylglutathione
-
 ?
4.4.1.5 glutathione + methylglyoxal
-
 Streptococcus mutans UA159 S-D-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 LGL
-
 Streptococcus mutans

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.4.1.5 5 7.5 lgl mRNA levels are 3.5fold higher in cells grown at pH 5.0 than in cells grown at pH 7.5, levels of lgl transcript are increased 2.1fold in cells exposed to pH 5.5 for 2 h Streptococcus mutans