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Literature summary extracted from

  • Spiliotis, M.; Konrad, C.; Gelmedin, V.; Tappe, D.; Brueckner, S.; Moesch, H.U.; Brehm, K.
    Characterisation of EmMPK1, an ERK-like MAP kinase from Echinococcus multilocularis which is activated in response to human epidermal growth factor (2006), Int. J. Parasitol., 36, 1097-1112.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 Epidermal growth factor MPK1 is responsive to exogenous host epidermal growth factor, which increases MPK1 phosphorylation Echinococcus multilocularis
2.7.11.24 hepatocyte host hepatocytes lead to maximal induction of MPK1 phosphorylation Echinococcus multilocularis
2.7.11.24 serum host serum positively effects MPK1 phosphorylation Echinococcus multilocularis

Application

EC Number Application Comment Organism
2.7.11.24 medicine Echinococcus multilocularis metacestode is able to sense epidermal growth factor from the host which results in an activation of the parasite’s MAP kinase cascade. MPK1 contains all amino acid residues characteristic for MAP kinases, including a conserved TEY motif which identifies the protein as a member of the ERK subfamily of MAP kinases Echinococcus multilocularis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.24 entire reading frame encoding MPK1-A cloned into the pBAD adn pBAD/Thio expression system, heterologous expression in Escherichia coli Echinococcus multilocularis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.24 Mg2+
-
 Echinococcus multilocularis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.24 42000
-
 sequence analysis, Western blot analysis Echinococcus multilocularis

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Echinococcus multilocularis
-
 isolate H95
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.24
-
 Echinococcus multilocularis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 larva protein and its phosphorylated form present in the larval stages metacestode and protoscolex during in vitro cultivation and during an infection of the intermediate host Echinococcus multilocularis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + myelin basic protein
-
 Echinococcus multilocularis ADP + phosphorylated myelin basic protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 MAP kinase
-
 Echinococcus multilocularis
2.7.11.24 mitogen-activated protein kinase
-
 Echinococcus multilocularis
2.7.11.24 MPK1
-
 Echinococcus multilocularis