Literature summary extracted from

Colgan, S.M.; Tang, D.; Werstuck, G.H.; Austin, R.C.
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2 (2007), Int. J. Biochem. Cell Biol., 39, 1843-1851.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.24.85	A23187	-	Homo sapiens
3.4.24.85	homocysteine	-	Homo sapiens
3.4.24.85	thapsigargin	cells treated with thapsigargin exhibit proteolytic cleavage of SREBP-2	Homo sapiens
3.4.24.85	tunicamycin	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.85	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.85	HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.85	SREBP NH2-522 fragment + H2O	-	Homo sapiens	NH2-484 fragment + 38 aa fragment	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.85	site-2 protease	-	Homo sapiens
3.4.24.85	SREBP-2 proteinase	-	Homo sapiens
3.4.24.85	sterol regulatory element binding protein-2 proteinase	-	Homo sapiens

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Release 2023.1 (January 2023)