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Literature summary extracted from

  • Crone, E.J.; Sutherland, T.D.; Campbell, P.M.; Coppin, C.W.; Russell, R.J.; Oakeshott, J.G.
    Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo (2007), Insect Biochem. Mol. Biol., 37, 540-549.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.59 diisopropyl fluorophosphate 50% inhibition at 0.002 mM Drosophila melanogaster
3.1.1.59 hydroprene 50% inhibition at 8 mM Drosophila melanogaster
3.1.1.59 kinoprene 50% inhibition at 2 mM Drosophila melanogaster
3.1.1.59 methoprene 50% inhibition at 2 mM Drosophila melanogaster
3.1.1.59 octylthiotrifluoropropanone 50% inhibition below 1 nM Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.59 1.3
-
 juvenile hormone III 10R isomer of juvenile hormone III Drosophila melanogaster
3.1.1.59 1.5
-
 juvenile hormone III racemic juvenile hormone III Drosophila melanogaster
3.1.1.59 2.4
-
 juvenile hormone III 10S isomer of juvenile hormone III Drosophila melanogaster
3.1.1.59 3.7
-
 methyl farnesoate
-
 Drosophila melanogaster
3.1.1.59 4.2
-
 juvenile hormone I
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.59 additional information Drosophila melanogaster there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.59 Drosophila melanogaster A1ZA98
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.59 juvenile hormone I + H2O
-
 Drosophila melanogaster juvenile hormone I acid + methanol
-
 ?
3.1.1.59 juvenile hormone III + H2O 10R-juvenile hormone III is the natural isomer Drosophila melanogaster juvenile hormone III acid + methanol
-
 ?
3.1.1.59 methyl farnesoate + H2O
-
 Drosophila melanogaster methanol + farnesoic acid
-
 ?
3.1.1.59 additional information there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity Drosophila melanogaster ?
-
 ?
3.1.1.59 additional information no activity with juvenile hormone II Drosophila melanogaster ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.1.59 0.8
-
 juvenile hormone III 10S isomer of juvenile hormone III Drosophila melanogaster
3.1.1.59 1
-
 juvenile hormone III racemic juvenile hormone III Drosophila melanogaster
3.1.1.59 1.1
-
 juvenile hormone III 10R isomer of juvenile hormone III Drosophila melanogaster
3.1.1.59 1.6
-
 juvenile hormone I
-
 Drosophila melanogaster
3.1.1.59 3
-
 methyl farnesoate
-
 Drosophila melanogaster