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Literature summary extracted from

  • Moya-Garcia, A.A.; Pino-Angeles, A.; Sanchez-Jimenez, F.
    New structural insights to help in the search for selective inhibitors of mammalian pyridoxal 5-phosphate-dependent histidine decarboxylase (2006), Inflamm. Res., 55, S55-S56.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.22 DNA and amino acid sequence analysis, phylogenetic tree, biocomputational analysis of the evolutionary specificity-determinants in decreasing order: Y279, D315, P85, M97, S77, L132, R361, Y83, D348, S112, Q150, G40, L377, R415, A82, W75, P70, R286, L285, and I430, overview Raoultella planticola

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Raoultella planticola the enzyme has roles in inflammatory and neurological diseases, and in progression of several cancer types histamine + CO2
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4.1.1.22 additional information Raoultella planticola biocomputational analysis of the evolutionary specificity-determinants in decreasing order: Y279, D315, P85, M97, S77, L132, R361, Y83, D348, S112, Q150, G40, L377, R415, A82, W75, P70, R286, L285, and I430, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Raoultella planticola
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine the enzyme has roles in inflammatory and neurological diseases, and in progression of several cancer types Raoultella planticola histamine + CO2
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 ?
4.1.1.22 L-histidine the enzyme is a group II pyridoxal 5’-phosphate-dependent L-amino acid decarboxylase, L-aaDCII Raoultella planticola histamine + CO2
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 ?
4.1.1.22 additional information biocomputational analysis of the evolutionary specificity-determinants in decreasing order: Y279, D315, P85, M97, S77, L132, R361, Y83, D348, S112, Q150, G40, L377, R415, A82, W75, P70, R286, L285, and I430, overview Raoultella planticola ?
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 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 More monomeric structure modeling Raoultella planticola

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 DCHS
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 Raoultella planticola

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate dependent on Raoultella planticola