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Literature summary extracted from

  • McCollister, B.D.; Myers, J.T.; Jones-Carson, J.; Voelker, D.R.; Vazquez-Torres, A.
    Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium (2007), Infect. Immun., 75, 5346-5352.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information extracts from ASM-deficient macrophages sustain limited enzymatic synthesis of NBD-ceramide from NBD-sphingomyelin, phenotypes of ASM-/- and ASM+/+ macrophages, intracellular survival of Salmonella enterica serovar typhimurium is enhanced in macrophages lacking ASM, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 additional information Salmonella enterica serovar typhimurium infection reduces ASM activity, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 extracellular secreted enzyme, infection of macrophages with Salmonella enterica serovar typhimurium stimulates extracellular ASM secretion Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Mus musculus constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar typhimurium, Salmonella infection reduces ASM activity, overview N-acylsphingosine + choline phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Mus musculus
-
heterozygous sv129 x BL/6 background mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 epithelial cell airway Mus musculus
-
3.1.4.12 macrophage peritoneal Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar typhimurium, Salmonella infection reduces ASM activity, overview Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
Mus musculus
3.1.4.12 ASM
-
Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5
-
assay at Mus musculus