EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.12 | additional information | extracts from ASM-deficient macrophages sustain limited enzymatic synthesis of NBD-ceramide from NBD-sphingomyelin, phenotypes of ASM-/- and ASM+/+ macrophages, intracellular survival of Salmonella enterica serovar typhimurium is enhanced in macrophages lacking ASM, overview | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | additional information | Salmonella enterica serovar typhimurium infection reduces ASM activity, overview | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.12 | extracellular | secreted enzyme, infection of macrophages with Salmonella enterica serovar typhimurium stimulates extracellular ASM secretion | Mus musculus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | Mus musculus | constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar typhimurium, Salmonella infection reduces ASM activity, overview | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Mus musculus | - |
heterozygous sv129 x BL/6 background mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | epithelial cell | airway | Mus musculus | - |
3.1.4.12 | macrophage | peritoneal | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | sphingomyelin + H2O | - |
Mus musculus | N-acylsphingosine + choline phosphate | - |
? | |
3.1.4.12 | sphingomyelin + H2O | constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar typhimurium, Salmonella infection reduces ASM activity, overview | Mus musculus | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | acid sphingomyelinase | - |
Mus musculus |
3.1.4.12 | ASM | - |
Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 37 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.12 | 5 | - |
assay at | Mus musculus |