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Literature summary extracted from

  • Fernaays, M.M.; Lesse, A.J.; Cai, X.; Murphy, T.F.
    Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae (2006), Infect. Immun., 74, 5860-5870.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.72 gene igaB, DNA and amino acid sequence determination and analysis, genetic organization of the igaB locus, overview Haemophilus influenzae

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.72 additional information construction of igaB mutants and igaA/igaB double mutants of strain 11P6H Haemophilus influenzae
3.4.24.13 additional information Blastx analysis shows that the igaB gene is homologous to the IgA1 protease genes of Neisseria gonorrhoeae and Neisseria meningitidis. The degree of homology of igaB to neisserial iga genes is greater than the homology of igaB to Haemophilus iga genes Haemophilus influenzae
3.4.24.13 additional information mutants that are deficient in iga, igaB, and both genes are constructed in Haemophilus influenzae strain 11P6H. Analysis of these mutants indicates that igaB is the primary mediator of IgA1 protease activity in this strain Haemophilus influenzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.72 human immunoglobulin A1 + H2O Haemophilus influenzae
-
 ?
-
 ?
3.4.21.72 additional information Haemophilus influenzae the type 2 IgA1 protease is a potential virulence factor in Haemophilus influenzae, the igaB encoded enzyme is the primary mediator of IgA1 protease activity in strain 11P6H, not the type 1 IgA1 protease encoded by igaA, IgA1 proteases are classified as type 1 or type 2 based on the specific site of enzymatic cleavage in the hinge region of the IgA1 molecule ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.72 Haemophilus influenzae
-
 strain 11P6H, a strain isolated from the sputum of a patient with chronic obstructive pulmonary disease, experiencing an exacerbation, gene igaB
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3.4.24.13 Haemophilus influenzae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.72 additional information distribution of igaB among clinical isolates of nontypeable Haemophilus influenzae, overview Haemophilus influenzae
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3.4.24.13 additional information reverse transcriptase PCR shows that igB is transcribed in Haemophilus influenza Haemophilus influenzae
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.72 additional information
-
-
 Haemophilus influenzae
3.4.24.13 additional information
-
 IgA1 protease activity assays on 20 clinical isolates indicates that the igaB gene is associated with increased levels of IgA1 protease activity Haemophilus influenzae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.72 human immunoglobulin A1 + H2O
-
 Haemophilus influenzae ?
-
 ?
3.4.21.72 additional information the type 2 IgA1 protease is a potential virulence factor in Haemophilus influenzae, the igaB encoded enzyme is the primary mediator of IgA1 protease activity in strain 11P6H, not the type 1 IgA1 protease encoded by igaA, IgA1 proteases are classified as type 1 or type 2 based on the specific site of enzymatic cleavage in the hinge region of the IgA1 molecule Haemophilus influenzae ?
-
 ?
3.4.24.13 Immunoglobulin A1 + H2O
-
 Haemophilus influenzae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.72 IgA1 protease
-
 Haemophilus influenzae
3.4.21.72 immunoglobulin A1 protease
-
 Haemophilus influenzae
3.4.21.72 type 2 IgA1 protease
-
 Haemophilus influenzae
3.4.24.13 IgA1 protease
-
 Haemophilus influenzae
3.4.24.13 igaB
-
 Haemophilus influenzae
3.4.24.13 igaB represents a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenza Haemophilus influenzae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.72 37
-
 assay at Haemophilus influenzae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.72 7.4
-
 assay at Haemophilus influenzae