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Literature summary extracted from

  • Krauth, M.T.; Agis, H.; Aichberger, K.J.; Simonitsch-Klupp, I.; Muellauer, L.; Mayerhofer, M.; Boehm, A.; Horny, H.P.; Valent, P.
    Immunohistochemical detection of histidine decarboxylase in neoplastic mast cells in patients with systemic mastocytosis (2006), Hum. Pathol., 37, 439-447.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.1.22 diagnostics HDC can be used as an immunohistochemical marker for the detection of immature neoplastic mast cells in patients with mast cell-proliferative disorders Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.22 quantitative expression analysis in mast cells of different maturation stage of patients with systemic mastocytosis, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 alpha-Fluoromethylhistidine alpha-FMH, specific inhibitor of HDC Homo sapiens
4.1.1.22 additional information treatment of mast cells in systemic mastocytosis with pharmacologic inhibitors prednisone, IFNalpha, and 2CdA only slightly inhibit expression of HDC, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Homo sapiens HDC is the key enzyme involved in histamine production histamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 basophil in basophilic leukemia Homo sapiens
-
4.1.1.22 bone marrow from patients with mastocytosis Homo sapiens
-
4.1.1.22 HMC-1 cell
-
 Homo sapiens
-
4.1.1.22 marrow cell immature, low expression level in basophilic leukemia Homo sapiens
-
4.1.1.22 mast cell neoplastic mast cells in patients with systemic mastocytosis, including MC leukemia and MC sarcoma, expression in mast cells of different maturation stage, immunohistochemic detection and quantitative expression analysis Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Homo sapiens histamine + CO2
-
 ?
4.1.1.22 L-histidine HDC is the key enzyme involved in histamine production Homo sapiens histamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Homo sapiens