EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | TNFalpha | activates the enzyme, which is prevented by pentoxifylline | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.12 | additional information | ASMase knockdown by siRNA decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 and JNK activation, ASMase down-regulation by siRNA protects the liver against ischemia/reperfusion-induced damage, overview | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | imipramine | ASMase inhibitor | Mus musculus | |
3.1.4.12 | additional information | pentoxifylline treatment preventsTNFupregulation and ASMase activation | Mus musculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | Mg2+ | dependent on, ASMase | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | additional information | Mus musculus | ASMase inhibition decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 activation, overview, the enzyme is involved in hepatic ischemia/reperfusion damage, ceramide generated from ASMase plays a key role in I/R-induced liver damage, molecular mechanisms, overview | ? | - |
? | |
3.1.4.12 | sphingomyelin + H2O | Mus musculus | the enzyme is important in ceramide metabolism, overview | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.12 | liver | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | additional information | ASMase inhibition decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 activation, overview, the enzyme is involved in hepatic ischemia/reperfusion damage, ceramide generated from ASMase plays a key role in I/R-induced liver damage, molecular mechanisms, overview | Mus musculus | ? | - |
? | |
3.1.4.12 | sphingomyelin + H2O | - |
Mus musculus | N-acylsphingosine + choline phosphate | - |
? | |
3.1.4.12 | sphingomyelin + H2O | the enzyme is important in ceramide metabolism, overview | Mus musculus | N-acylsphingosine + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | acidic sphingomyelinase | - |
Mus musculus |
3.1.4.12 | aSMase | - |
Mus musculus |