Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Llacuna, L.; Mari, M.; Garcia-Ruiz, C.; Fernandez-Checa, J.C.; Morales, A.
    Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury (2006), Hepatology, 44, 561-572.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 TNFalpha activates the enzyme, which is prevented by pentoxifylline Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information ASMase knockdown by siRNA decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 and JNK activation, ASMase down-regulation by siRNA protects the liver against ischemia/reperfusion-induced damage, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 imipramine ASMase inhibitor Mus musculus
3.1.4.12 additional information pentoxifylline treatment preventsTNFupregulation and ASMase activation Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Mg2+ dependent on, ASMase Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Mus musculus ASMase inhibition decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 activation, overview, the enzyme is involved in hepatic ischemia/reperfusion damage, ceramide generated from ASMase plays a key role in I/R-induced liver damage, molecular mechanisms, overview ?
-
?
3.1.4.12 sphingomyelin + H2O Mus musculus the enzyme is important in ceramide metabolism, overview N-acylsphingosine + choline phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 liver
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information ASMase inhibition decreases ceramide generation during ischemia/reperfusion, and attenuates serum ALT levels, hepatocellular necrosis, cytochrome c release, and caspase-3 activation, overview, the enzyme is involved in hepatic ischemia/reperfusion damage, ceramide generated from ASMase plays a key role in I/R-induced liver damage, molecular mechanisms, overview Mus musculus ?
-
?
3.1.4.12 sphingomyelin + H2O
-
Mus musculus N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O the enzyme is important in ceramide metabolism, overview Mus musculus N-acylsphingosine + choline phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acidic sphingomyelinase
-
Mus musculus
3.1.4.12 aSMase
-
Mus musculus