Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Pabba, J.; Rempel, B.P.; Withers, S.G.; Vasella, A.
    Synthesis of glycaro-1,5-lactams and tetrahydrotetrazolopyridine-5-carboxylates: inhibitors of beta-D-glucuronidase and alpha-L-iduronidase (2006), Helv. Chim. Acta, 89, 635-666.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.76 (5R,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
 Homo sapiens
3.2.1.76 (5R,6S,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
 Homo sapiens
3.2.1.76 (5S,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate
-
 Homo sapiens
3.2.1.76 6-sodium-5-amino-5-deoxy-L-idarate-1,5-lactam
-
 Homo sapiens
3.2.1.76 additional information not inhibited by 6-sodium 5-amino-5-deoxy-D-glucarate-1,5-lactam, 6-sodium 5-amino-5-deoxy-D-galactarate-1,5-lactam, 6-sodium 5-amino-5-deoxy-L-altrarate-1,5-lactam, and 4-amino-4,5-dideoxy-L-arabinaro-1,4-lactam Homo sapiens
3.2.1.76 [(2S,3R,4R)-3,4-dihydroxy-5-oxotetrahydrofuran-2-yl](hydroxy)acetic acid competitive inhibitor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.76 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.76 4-methylumbelliferyl-alpha-L-iduronide + H2O
-
 Homo sapiens 4-methylumbelliferone + alpha-L-iduronic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.76 alpha-L-iduronidase
-
 Homo sapiens
3.2.1.76 IDU
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.76 0.094
-
 6-sodium-5-amino-5-deoxy-L-idarate-1,5-lactam at pH 4.5 and 37°C Homo sapiens
3.2.1.76 1.3
-
 (5S,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate at pH 4.5 and 37°C Homo sapiens
3.2.1.76 5
-
 (5R,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate Ki above 5 mM, at pH 4.5 and 37°C Homo sapiens
3.2.1.76 5
-
 (5R,6S,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxytetrazolo[1,2-a]pyridine-5-carboxylate Ki above 5 mM, at pH 4.5 and 37°C Homo sapiens