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Literature summary extracted from

  • Rigden, D.J.; Botzki, A.; Nukui, M.; Mewbourne, R.B.; Lamani, E.; Braun, S.; von Angerer, E.; Bernhardt, G.; Dove, S.; Buschauer, A.; Jedrzejas, M.J.
    Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole (2006), Glycobiology, 16, 757-765.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.2.1 hanging drop vapor diffusion method, 1-decyl-2-(4-sulfamoyloxyphenyl)-1-indol-6-yl sulfamate is co-crystallized in a complex with Streptococcus pneumoniae Hyal Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.2.1 1-decyl-2-(4-sulfamoyloxyphenyl)-1-indol-6-yl sulfamate
-
 Streptococcus agalactiae
4.2.2.1 1-decyl-2-(4-sulfamoyloxyphenyl)-1H-indol-6-yl sulfamate inhibitor fits in the enzymatic active site via interactions resembling the binding mode of the natural hyaluronan substrate Streptococcus agalactiae
4.2.2.1 L-ascorbic acid
-
 Streptococcus agalactiae
4.2.2.1 L-ascorbic acid
-
 Streptococcus pneumoniae
4.2.2.1 L-ascorbic acid-6-hexadecanoate
-
 Streptococcus agalactiae
4.2.2.1 L-ascorbic acid-6-hexadecanoate
-
 Streptococcus pneumoniae
4.2.2.1 additional information IC50 for 1,3-diacetylbenzimidazole-2-thione is above 0.1 mM Streptococcus pneumoniae
4.2.2.1 N-(3-phenylpropionyl)-benzoxazole-2-thione
-
 Streptococcus agalactiae

Organism

EC Number Organism UniProt Comment Textmining
4.2.2.1 Streptococcus agalactiae
-
-
-
4.2.2.1 Streptococcus agalactiae 4755
-
-
-
4.2.2.1 Streptococcus pneumoniae Q54873
-
-

Synonyms

EC Number Synonyms Comment Organism
4.2.2.1 SagHyal
-
 Streptococcus agalactiae
4.2.2.1 SpnHyal
-
 Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.2.1 0.0042
-
 pH 5.0 Streptococcus agalactiae L-ascorbic acid-6-hexadecanoate
4.2.2.1 0.011
-
 pH 5.0 Streptococcus agalactiae 1-decyl-2-(4-sulfamoyloxyphenyl)-1-indol-6-yl sulfamate
4.2.2.1 0.015
-
 pH 5.0 Streptococcus agalactiae N-(3-phenylpropionyl)-benzoxazole-2-thione
4.2.2.1 0.1
-
 pH 5.0 Streptococcus pneumoniae L-ascorbic acid-6-hexadecanoate
4.2.2.1 6.1
-
 pH 5.0 Streptococcus agalactiae L-ascorbic acid
4.2.2.1 34.8
-
 pH 5.0 Streptococcus pneumoniae L-ascorbic acid