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Literature summary extracted from

  • Inada, H.; Ito, H.; Satterlee, J.; Sengupta, P.; Matsumoto, K.; Mori, I.
    Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans (2006), Genetics, 172, 2239-2252.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 full-length genomic gcy gene sequence fused to the GFP gene and injected into wild-type animals Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 additional information double mutants for gcy genes show defects in thermotaxis, triple mutants for the gcy genes show severe defects in thermotaxis but respond normally to odorants and NaCl, abnormal phenotype of the gcy triple mutants can be rescued by expression of any one of the three GCY proteins, gcy-8, gcy-18, and gcy-23. In the AFD neurons no defects in thermotaxis behaviors in gcy single mutants Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Caenorhabditis elegans
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variety Bristol (N2)
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4.6.1.2 Caenorhabditis elegans Q9GYQ4 variety Bristol (N2)
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Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.2
-
Caenorhabditis elegans

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 neuron expressed specifically in the AFD thermosensory neurons Caenorhabditis elegans
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
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Caenorhabditis elegans 3',5'-cyclic GMP + diphosphate regulation of intracellular cGMP concentration is essential for normal thermotaxis ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 gcy-18
-
Caenorhabditis elegans
4.6.1.2 gcy-23
-
Caenorhabditis elegans
4.6.1.2 gcy-8
-
Caenorhabditis elegans
4.6.1.2 receptor-type guanylyl cyclase
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Caenorhabditis elegans

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4.6.1.2 15 25
-
Caenorhabditis elegans