Literature summary extracted from

Shepard, J.L.; Amatruda, J.F.; Finkelstein, D.; Ziai, J.; Finley, K.R.; Stern, H.M.; Chiang, K.; Hersey, C.; Barut, B.; Freeman, J.L.; Lee, C.; Glickman, J.N.; Kutok, J.L.; Aster, J.C.; Zon, L.I.
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer (2007), Genes Dev., 21, 55-59.

Application

EC Number	Application	Comment	Organism
3.4.22.49	medicine	the results show that separase might be a tumor supressor gene	Danio rerio

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.22.49	additional information	analysis of the homozygous zebrafish mutant cds (cease&desist), bearing a mutation in the separase gene, reveals high levels of polyploidy and aneuploidy, spindle defects, and a mitotic exit delay in mutant embryos. Carcinogenesis studies demonstrate that cds heterozygous adults have an eightfold increase in the percentage of fish bearing epithelial tumors	Danio rerio

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.49	Danio rerio	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.49	separase	-	Danio rerio

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Release 2023.1 (January 2023)