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Literature summary extracted from

  • Perez Vidakovics, M.L.; Lamberti, Y.; van der Pol, W.L.; Yantorno, O.; Rodriguez, M.E.
    Adenylate cyclase influences filamentous haemagglutinin-mediated attachment of Bordetella pertussis to epithelial alveolar cells (2006), FEMS Immunol. Med. Microbiol., 48, 140-147.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.6.1.1 additional information ACT enhances the adhesive functions of filamentous haemagglutinin and modifies the performance of the filamentous haemagglutinin heparin-inhibitable carbohydrate binding site Bordetella pertussis

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.1 additional information mutants lacking either filamentous haemagglutinin or ACT (strain Bp3183) show significantly decreased adherence to human epithelial respiratory cells, lack of ACT does not affect filamentous haemagglutinin cellular expression, attachment level of the ACT-deficient mutant to A549 cells is not affected by the presence of heparin Bordetella pertussis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 additional information antibodies against ACT fail to block Bordetella pertussis attachment to human A549 cells Bordetella pertussis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 outer membrane
-
 Bordetella pertussis 19867
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Mg2+
-
 Bordetella pertussis

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Bordetella pertussis
-
-
-
4.6.1.1 Bordetella pertussis Tohama I
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 ACT
-
 Bordetella pertussis
4.6.1.1 adenylate cyclase toxin
-
 Bordetella pertussis