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Literature summary extracted from

  • Ferry, G.; Giganti, A.; Coge, F.; Bertaux, F.; Thiam, K.; Boutin, J.A.
    Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal (2007), FEBS Lett., 581, 3572-3578.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 cloned from 129S6/Sv mouse brain, expression in COS-7 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.39 DELTA202-363 COS cells transfected with mutated ATX express catalytically inactive phosphodiesterase and lysophospholipase D. Lethality of the ATX-/-embryos. ATX-dependent LPA production is due to the catalytic activity of the enzyme Mus musculus
3.1.4.39 T210A inactive enzyme, generation of a mouse line displaying an inactivated ATX gene product. Lethality of the ATX-/-embryos. ATX-dependent LPA production is due to the catalytic activity of the enzyme. Clone identified, by both PCR and Southern blot as targeted at the Atx locus Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 lyso-phosphatidylcholine + H2O
-
 Mus musculus lyso-phosphatidic acid + choline central in some key metabolic deregulations ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 autotaxin member of the phosphodiesterase family of enzymes Mus musculus
3.1.4.39 lysophospholipase D
-
 Mus musculus