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Literature summary extracted from

  • Mechtcheriakova, D.; Wlachos, A.; Sobanov, J.; Bornancin, F.; Zlabinger, G.; Baumruker, T.; Billich, A.
    FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3 (2007), FEBS Lett., 581, 3063-3068.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.4 medicine LPP3 acts as an ecto-phosphatase that contributes to the equilibration between FTY720 and FTY720-P in vivo Mus musculus
3.1.3.4 medicine LPP3 acts as an ecto-phosphatase that contributes to the equilibration between FTY720 and FTY720-P in vivo Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 expressed as untagged proteins in HUVEC cells or in HEK-293 cells Mus musculus
3.1.3.4 expressed either as untagged proteins or as Flag- or EGFP-tagged enzymes in HUVEC cells or in HEK-293 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 endoplasmic reticulum LPP1 Homo sapiens 5783
-
3.1.3.4 plasma membrane LPP2 and LPP3 Homo sapiens 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens
-
-
-
3.1.3.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 HEK-293 cell LPP3 Homo sapiens
-
3.1.3.4 HUVEC cell LPP3 Homo sapiens
-
3.1.3.4 kidney
-
 Homo sapiens
-
3.1.3.4 lung
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.4 0.00035
-
 LPP3 activity against FTY720-P Homo sapiens
3.1.3.4 0.00285
-
 LPP3 activity against sphingosine 1-phosphate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 dihydro-sphingosine-1-phosphate + H2O all LPPs Mus musculus dihydro-sphingosine + phosphate
-
 ?
3.1.3.4 dihydro-sphingosine-1-phosphate + H2O all LPPs Homo sapiens dihydro-sphingosine + phosphate
-
 ?
3.1.3.4 FTY720-phosphate + H2O LPP3 Mus musculus FTY720 + phosphate
-
 ?
3.1.3.4 FTY720-phosphate + H2O LPP3 Homo sapiens FTY720 + phosphate
-
 ?
3.1.3.4 lyso-phosphatidic acid + H2O all LPPs Mus musculus monoacylglycerol + phosphate
-
 ?
3.1.3.4 lyso-phosphatidic acid + H2O all LPPs Homo sapiens monoacylglycerol + phosphate
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O all LPPs Mus musculus sphingosine + phosphate
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O all LPPs Homo sapiens sphingosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipid phosphate phosphatase 3
-
 Mus musculus
3.1.3.4 lipid phosphate phosphatase 3
-
 Homo sapiens
3.1.3.4 lipid phosphate phosphohydrolase
-
 Mus musculus
3.1.3.4 lipid phosphate phosphohydrolase
-
 Homo sapiens
3.1.3.4 LPP1
-
 Mus musculus
3.1.3.4 LPP1
-
 Homo sapiens
3.1.3.4 LPP2
-
 Homo sapiens
3.1.3.4 LPP3
-
 Mus musculus
3.1.3.4 LPP3
-
 Homo sapiens