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Literature summary extracted from

  • Csala, M.; Margittai, E.; Senesi, S.; Gamberucci, A.; Banhegyi, G.; Mandl, J.; Benedetti, A.
    Inhibition of hepatic glucose 6-phosphatase system by the green tea flavanol epigallocatechin gallate (2007), FEBS Lett., 581, 1693-1698.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.9 D-glucose reduces the G6Pase activity both in intact and permeabilized liver microsomes in a concentration-dependent manner. Extent of inhibition is comparable with that achieved by epigallocatechin gallate in intact microsomes Rattus norvegicus
3.1.3.9 epicatechin gallate acts similarly but less efficiently than epigallocatechin gallate Rattus norvegicus
3.1.3.9 epigallocatechin gallate increases latency of G6Pase, inhibitory effect is greater in intact than in permeabilized microsomes. It does not hinder microsomal D-glucose 6-phosphate uptake. Reduces activity of G6Pase through the inhibition of glucose efflux from the endoplasmic reticulum lumen; inhibition of enzyme in intact, but not in permeabilized microsome. Epigallocatechin gallate does not hinder microsomal glucose uptake, but inhibits microsomal glucose efflux thus inhibiting the enzyme through an elevated luminal glucose level Rattus norvegicus
3.1.3.9 gallocatechin gallate increases latency of G6Pase, inhibitory effect is greater in intact than in permeabilized microsomes Rattus norvegicus
3.1.3.9 additional information propyl gallate has no effect Rattus norvegicus
3.1.3.9 S3483 only depresses G6Pase activity in intact microsomes, thus increases latency Rattus norvegicus
3.1.3.9 vanadate reduces activity both in intact and permeabilized microsomes and decreases latency Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.9 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.9 liver
-
 Rattus norvegicus
-
3.1.3.9 liver microsome Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.9 47.5
-
 intact microsome, presence of 0.1 mM epigallocatechin gallate Rattus norvegicus
3.1.3.9 80
-
 intact microsome Rattus norvegicus
3.1.3.9 107
-
 permeabilized microsome, presence of 0.1 mM epigallocatechin gallate Rattus norvegicus
3.1.3.9 124
-
 permeabilized microsome Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.9 D-glucose 6-phosphate + H2O
-
 Rattus norvegicus D-glucose + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.9 G6Pase
-
 Rattus norvegicus
3.1.3.9 glucose 6-phosphatase
-
 Rattus norvegicus