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Literature summary extracted from
- Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase (2007), FEBS J., 274, 1183-1191.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.8.1 | additional information | PON1 is an attractive as a candidate bioscavenger of organophosphorus compounds | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.8.1 | additional information | - |
additional information | - |
Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.8.1 | Ca2+ | dependent on | Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.8.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.8.1 | serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.8.1 | additional information | residues Phe222 and His115 are important in organophosphorus substrate specificity and catalysis | Homo sapiens | ? | - |
? | |
| 3.1.8.1 | O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate + H2O | i.e. VX, a highly toxic organophosphorus nerve agent, stereospecific hydrolysis | Homo sapiens | ? | - |
? | |
| 3.1.8.1 | sarin + H2O | a highly toxic organophosphorus nerve agent, stereospecific hydrolysis | Homo sapiens | methylphosphonofluoride acid + ? | - |
? | |
| 3.1.8.1 | soman + H2O | i.e. pinacolyl methylphosphonofluoridate, a highly toxic organophosphorus nerve agent, stereospecific hydrolysis | Homo sapiens | methylphosphonofluoride acid + 3,3-dimethylbutan-2-ol | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.8.1 | More | PON1 is a six-fold beta-propeller enzyme | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.8.1 | paraoxonase 1 | - |
Homo sapiens |
| 3.1.8.1 | PON1 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.8.1 | 22 | - |
assay at room temperature | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.8.1 | 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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