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Literature summary extracted from

  • Wu, F.; Yu, J.; Gehring, H.
    Inhibitory and structural studies of novel coenzyme-substrate analogs of human histidine decarboxylase (2007), FASEB J., 22, 890-897.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.22 additional information 12-O-tetradecanoylphorbol-13-acetate induces the enzyme Homo sapiens

Application

EC Number Application Comment Organism
4.1.1.22 drug development HDC is a potential target to attenuate histamine production in certain pathological states using structure-based inhibitors, design, synthesis, and test of potentially membrane-permeable pyridoxyl-substrate conjugates as inhibitors for human HDC and modeling of an active site for hHDC, which is compatible with the experimental data, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 additional information design, synthesis, and test of potentially membrane-permeable pyridoxyl-substrate conjugates as inhibitors for human HDC and modeling of an active site for hHDC, which is compatible with the experimental data, structure-activity relationship, overview Homo sapiens
4.1.1.22 pyridoxyl-histidine methyl ester conjugate structure-based inhibitor, binding structure Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Homo sapiens
-
 histamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Homo sapiens P19113
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.22 L-histidine = histamine + CO2 structure-activity relationship, active site structure, molecular modeling, the imidazole ring is located in a pocket composed of residues Tyr-81B, Asn-302B, Ser-304B, Lys-305B, Leu-102A, Phe-104A, and Ser-354A Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 HMC-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Homo sapiens histamine + CO2
-
 ?
4.1.1.22 L-histidine the binding site of HDC does not tolerate groups other than the imidazole side chain of histidine Homo sapiens histamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 More structure molecular modeling Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.22 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate dependent on Homo sapiens