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Literature summary extracted from

  • Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.
    Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs (2006), FASEB J., 20, 1855-1864.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.2
-
 Homo sapiens
3.1.2.20
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.2 0.0016
-
 tetradecanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.002
-
 hexadecanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.002
-
 eicosanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0024
-
 palmitoleoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0024
-
 octadecanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0028
-
 tetradecanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0028
-
 octadecanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0036
-
 hexadecanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0036
-
 dodecanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0041
-
 oleoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0045
-
 palmitoleoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0048
-
 eicosanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0061
-
 oleoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0358
-
 decanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.0403
-
 decanoyl-CoA
-
 Homo sapiens
3.1.2.2 0.089
-
 dodecanoyl-CoA
-
 Homo sapiens
3.1.2.20 0.014
-
 succinyl-CoA
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 cytosol
-
 Homo sapiens 5829
-
3.1.2.2 mitochondrion
-
 Homo sapiens 5739
-
3.1.2.20 peroxisome
-
 Homo sapiens 5777
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Homo sapiens P49753
-
-
3.1.2.2 Homo sapiens Q86TX2
-
-
3.1.2.20 Homo sapiens Q3I5F7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 heart strong expression Homo sapiens
-
3.1.2.2 heart strong expression. ACOT2 is much more strongly expressed than ACOT1 Homo sapiens
-
3.1.2.2 kidney strong expression Homo sapiens
-
3.1.2.2 liver strong expression Homo sapiens
-
3.1.2.2 liver strong expression. ACOT2 is much more strongly expressed than ACOT1 Homo sapiens
-
3.1.2.2 muscle strong expression Homo sapiens
-
3.1.2.2 muscle strong expression. ACOT2 is much more strongly expressed than ACOT1 Homo sapiens
-
3.1.2.2 pancreas weak expression Homo sapiens
-
3.1.2.2 placenta weak expression Homo sapiens
-
3.1.2.20 heart weak expression Homo sapiens
-
3.1.2.20 kidney strongest expression in liver and kidney Homo sapiens
-
3.1.2.20 liver strongest expression in liver and kidney Homo sapiens
-
3.1.2.20 muscle weak expression Homo sapiens
-
3.1.2.20 placenta weak expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 decanoyl-CoA + H2O
-
 Homo sapiens CoA + decanoate
-
 ?
3.1.2.2 dodecanoyl-CoA + H2O
-
 Homo sapiens CoA + dodecanoate
-
 ?
3.1.2.2 eicosanoyl-CoA + H2O
-
 Homo sapiens CoA + eicosanoic acid
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O
-
 Homo sapiens CoA + hexadecanoate
-
 ?
3.1.2.2 octadecanoyl-CoA + H2O
-
 Homo sapiens CoA + octadecanoate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Homo sapiens CoA + oleic acid
-
 ?
3.1.2.2 palmitoleoyl-CoA + H2O
-
 Homo sapiens CoA + palmitoleic acid
-
 ?
3.1.2.2 tetradecanoyl-CoA + H2O
-
 Homo sapiens CoA + tetradecanoate
-
 ?
3.1.2.20 dodecanoyl-CoA + H2O
-
 Homo sapiens CoA + dodecanoate
-
 ?
3.1.2.20 eicosanoyl-CoA + H2O
-
 Homo sapiens CoA + eicosanoic acid
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O
-
 Homo sapiens CoA + hexadecanoate
-
 ?
3.1.2.20 additional information ACOT4 protein is active on succinyl-CoA and medium to long chain acyl-CoAs. Human ACOT4 gene has acquired the functions of three mouse genes by a functional convergent evolution Homo sapiens ?
-
 ?
3.1.2.20 octadecanoyl-CoA + H2O
-
 Homo sapiens CoA + octadecanoate
-
 ?
3.1.2.20 succinyl-CoA + H2O
-
 Homo sapiens CoA + succinate
-
 ?
3.1.2.20 tetradecanoyl-CoA + H2O
-
 Homo sapiens CoA + tetradecanoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.2 Acot1
-
 Homo sapiens
3.1.2.2 ACOT2
-
 Homo sapiens
3.1.2.2 acyl-CoA thioesterase 1
-
 Homo sapiens
3.1.2.2 acyl-CoA thioesterase 2
-
 Homo sapiens
3.1.2.2 acyl-coenzyme A thioester hydrolase 2a
-
 Homo sapiens
3.1.2.2 CTE-I
-
 Homo sapiens
3.1.2.2 CTE-Ia
-
 Homo sapiens
3.1.2.2 CTE-Ib
-
 Homo sapiens
3.1.2.2 long-chain acyl-CoA thioesterase 2
-
 Homo sapiens
3.1.2.2 ZAP128
-
 Homo sapiens
3.1.2.20 ACOT4
-
 Homo sapiens
3.1.2.20 acyl-CoA thioesterase
-
 Homo sapiens