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Literature summary extracted from

  • Lew, R.A.; Warner, F.J.; Hanchapola, I.; Yarski, M.A.; Manohar, J.; Burrell, L.M.; Smith, A.I.
    Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor (2008), Exp. Physiol., 93, 685-693.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 expressed in HEK 293-T cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 ramipril ACE-specific inhibitor Homo sapiens
3.4.17.23 Cu2+ 69% inhibition at 0.01 mM Homo sapiens
3.4.17.23 MLN-4760 0.0001 mM Homo sapiens
3.4.17.23 additional information not inhibited by Ca2+, Cd2+, Co2+, Mg2+, Mn2+, and Zn2+ Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.15.1 membrane
-
 Homo sapiens 16020
-
3.4.17.23 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Homo sapiens
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Homo sapiens
-
-
-
3.4.17.23 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.17.23 Ni3+-charged nitrilotriacetic acid-linked resin chromatography and and anti-Flag column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 blood plasma
-
 Homo sapiens
-
3.4.17.23 blood plasma ACE2 circulates in human plasma, but its activity is suppressed by the presence of an endogenous inhibitor Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Homo sapiens angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 hippuryl-L-His-L-Leu + H2O
-
 Homo sapiens hippuric acid + L-His-L-Leu
-
 ?
3.4.17.23 (7-methoxycoumarin-4-yl)-acetyl-Ala-Pro-Lys(2,4-dinitrophenyl) + H2O
-
 Homo sapiens (7-methoxycoumarin-4-yl)-acetyl-Ala-Pro + N6-(2,4-dinitrophenyl)-L-Lys
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Homo sapiens
3.4.15.1 angiotensin converting enzyme
-
 Homo sapiens
3.4.17.23 ACE2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.17.23 0.005
-
-
 Homo sapiens Cu2+