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Literature summary extracted from

  • Castillo, S.S.; Levy, M.; Wang, C.; Thaikoottathil, J.V.; Khan, E.; Goldkorn, T.
    Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis (2007), Exp. Cell Res., 313, 816-823.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information aSMase silencing by siRNA in human airway epithelial cells leads to increased caspase-3 cleavage Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens exposure to the NO donors promotes an increase in the protein-protein interaction between acidic sphingomyelinase and caspase-3, with aSMase sequestering caspase-3 and preventing its cleavage and inhibiting apoptosis, overview ?
-
 ?
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 A-549 cell
-
 Homo sapiens
-
3.1.4.12 epithelial cell airway Homo sapiens
-
3.1.4.12 HAE cell
-
 Homo sapiens
-
3.1.4.12 HBE-1 cell bronchial epithelial cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information exposure to the NO donors promotes an increase in the protein-protein interaction between acidic sphingomyelinase and caspase-3, with aSMase sequestering caspase-3 and preventing its cleavage and inhibiting apoptosis, overview Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acidic sphingomyelinase
-
 Homo sapiens
3.1.4.12 aSMase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.12 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 4.5
-
 acidic SMase assay at Homo sapiens